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Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity

26 Aug 2020

Abstract excerpt

The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the binding to the permissive cells. The receptor-binding domain (RBD) of SARS-CoV-2 S protein directly interacts with the human angiotensin-converting enzyme 2 (ACE2) on the host cell membrane. In this study, we used computational saturation mutagenesis approaches, including structure-based energy...

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PMID: 33006605
DOI: 10.1093/bib/bbaa233

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