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Article

STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice

6 Apr 2023

Abstract excerpt

Stimulator of interferon genes (STING) is a key mediator of type-I interferon (IFN-I) signaling in response to a variety of stimuli, but the contribution of STING to homeostatic processes is not fully characterized. Previous studies showed that ligand activation of STING limits osteoclast differentiation in vitro through the induction of IFNβ and IFN-I interferon-stimulated genes (ISGs). In a disease model (SAVI)...

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PMID: 37023130
DOI: 10.1073/pnas.2210409120

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