Article

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters

2025-11-26

Abstract excerpt

A key feature of rheumatoid arthritis (RA) is sexual dimorphism, with a higher incidence of RA in females. Myeloid cells are key drivers of the inflammatory effector phase of RA, but little is known about their contribution to a sexually dimorphic arthritis phenotype. We wished to utilize an arthritis model that recapitulates RA pathogenic myeloid cell subsets defined by single cell transcriptome analysis to inves...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee5195e2-a937-5ee9-bf84-54f6b68fed95
DOI: 10.1101/2025.11.24.690174

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clustersDOI 10.1101/2025.11.24.690174Read

Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ MacrophagesSemantic proximity Read

Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Inflammation Progression of Rheumatoid Arthritis by Inducing Age-Associated B Cell Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 PathwaySemantic proximity Read

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.Semantic proximity Read

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritisSemantic proximity Read

Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate diseaseSemantic proximity Read

Analysis of gene expression from systemic lupus erythematosus synovium reveals myeloid cell-driven pathogenesis of lupus arthritisSemantic proximity Read

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritisSemantic proximity Read

Identifying Immune Cell Infiltration and Effective Diagnostic Biomarkers in Rheumatoid Arthritis by Bioinformatics AnalysisSemantic proximity Read

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritisSemantic proximity Read

Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.Semantic proximity Read

Cell-Specific Gene Networks and Drivers in Rheumatoid Arthritis Synovial TissuesSemantic proximity Read

Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencingSemantic proximity Read