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Article

STAT wars: how STATopathies sabotage innate immunity.

Current opinion in allergy and clinical immunology - 1 Apr 2026

Bloomfield Markéta, Šabatková Klára, Paračková Zuzana

Abstract excerpt

PURPOSE OF REVIEW: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is a central conduit linking cytokine signals to immune and tissue homeostasis. Over the past decade, a rapidly expanding spectrum of STATopathies, monogenic inborn errors of immunity caused by loss or gain-of-function mutations in individual STAT genes, has been recognized. This review integrates emerging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41505725
DOI: 10.1097/ACI.0000000000001139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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