Back to search

Article

Therapeutic interleukin-2 rewires skeletal-immune circuits to reverse postmenopausal bone loss

2026-01-08

Abstract excerpt

Postmenopausal osteoporosis results from excessive osteoclast activity, but the immune circuits that limit osteoclastogenesis in the bone marrow remain poorly understood. Here, we tested a clinically accessible immunotherapy low-dose interleukin-2 (IL-2) as a therapeutic intervention in mice with established ovariectomy-induced bone loss, integrating microcomputed tomography imaging, single-cell transcriptomics, g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1bc144c8-a0f2-53cc-b591-3c4f1244425b
DOI
10.64898/2026.01.07.696511
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Therapeutic interleukin-2 rewires skeletal-immune circuits to reverse postmenopausal bone lossDOI 10.64898/2026.01.07.696511
Integrated single-cell and bulk RNA sequencing analysis reveal immune-related biomarkers in postmenopausal osteoporosisSemantic proximity
MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive ImmunitySemantic proximity
Immunology and boneSemantic proximity
TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesisSemantic proximity
Single-cell transcriptomic analysis reveals AP-1 downregulation remodels bone marrow environment and contributes to osteopenia in ovariectomized miceSemantic proximity
Biology of the RANKL–RANK–OPG System in Immunity, Bone, and BeyondSemantic proximity
STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in miceSemantic proximity
Emerging Roles of Natural Compounds in Osteoporosis: Regulation, Molecular Mechanisms and Bone RegenerationSemantic proximity
New Insights Into Osteoclast BiologySemantic proximity
IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1)Semantic proximity
Critical role for inflammasome-independent IL-1β production in osteomyelitis.Semantic proximity
Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone FormationSemantic proximity
Select a neighboring publication to make it the new centre.