Article

Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice

2024-11-06

Abstract excerpt

STING gain-of-function (GOF) mutations are associated with the severe autoinflammatory disease designated STING Associated Vasculopathy with onset in Infancy (SAVI). Mice with the STING GOF V154M mutation develop profound T cell lymphopenia, partly due to a blockage of T cell development in the thymus. To better characterize the mechanisms of peripheral T cell dysfunctions, we conducted a transcriptomic and phenot...

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Literature Corpus work: aaefe9b3-7c25-55d8-940a-d606e4dce33e
DOI: 10.1101/2024.11.01.621470

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