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Article

Common docking domain mutation E322K of the ERK2 gene is infrequent in oral squamous cell carcinomas.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2012

Valiathan Gopalakrishnan Mohan, Thenumgal Siji Jacob, Jayaraman Bhaskar, Palaniyandi Arunmozhi, Ramkumar Hemalatha, Jayakumar Keerthivasan, Bhaskaran Sajeev, Ramanathan Arvind

Abstract excerpt

BACKGROUND: Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/ RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated by cellular signals emanating at the cell membrane. Activated ERK2 translocates into the nucleus to transactivate genes that promote cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23464422
DOI: 10.7314/apjcp.2012.13.12.6155

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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