Article

Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosis

2021-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Among patients with obsessive-compulsive disorder (OCD), 65-85% manifest another psychiatric disorder concomitantly or at some other time point during their life. OCD is highly heritable, as are many of its comorbidities. A possible genetic heterogeneity of OCD in relation to its comorbid conditions, however, has not yet been exhaustively explored. We used a framework of different approaches to s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77da20a4-8a54-5e61-9e31-9ba318158b5b
DOI: 10.1101/2021.05.21.21257530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic heterogeneity across obsessive-compulsive disorder subgroups defined by a comorbid diagnosisDOI 10.1101/2021.05.21.21257530Read

Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid DiagnosisSemantic proximity Read

Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tic DisordersSemantic proximity Read

Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tourette syndromeSemantic proximity Read

Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics.Semantic proximity Read

Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders.Semantic proximity Read

Rare coding variation in OCD implicates shared genes with other psychiatric disordersSemantic proximity Read

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signalingSemantic proximity Read

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33 943 individuals from the general populationSemantic proximity Read

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.Semantic proximity Read

Genetics of obsessive-compulsive disorder.Semantic proximity Read

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.Semantic proximity Read

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and DisorderSemantic proximity Read