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Article

Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms.

Psychopharmacology - 1 Nov 2013

Cai Jun, Zhang Wen, Yi Zhenghui, Lu Weihong, Wu Zhiguo, Chen Jun, Yu Shunying, Fang Yiru, Zhang Chen

Abstract excerpt

RATIONALE: Clinical observations indicate that atypical antipsychotics, especially clozapine, induce obsessive-compulsive (OC) symptoms in schizophrenia patients. Recent data from neuroimaging and clinical trials suggest a role for altered glutamate neurotransmission in the etiology of OC disorder (OCD), and SLC1A1, GRIN2B, and GRIK2 have all been reported to regulate glutamate transmission and affect OCD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23660601
DOI: 10.1007/s00213-013-3137-2

Genes

GRIK2

Provenance

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