Article
FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.
Circulation research - 28 Apr 2023
Wong Doris, Auguste Gaëlle, Lino Cardenas Christian L, Turner Adam W, Chen Yixuan, Song Yipei, Ma Lijiang, Perry R Noah, Aherrahrou Redouane, Kuppusamy Maniselvan, Yang Chaojie, Mosquera Jose Verdezoto, Dube Collin J, Khan Mohammad Daud, Palmore Meredith, Kalra Jaspreet, Kavousi Maryam, Peyser Patricia A, Matic Ljubica, Hedin Ulf, Manichaikul Ani, Sonkusare Swapnil K, Civelek Mete, Kovacic Jason C, Björkegren Johan L M, Malhotra Rajeev, Miller Clint L
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS loci limits their translation into the clinic. Among these loci with unknown functions is UFL1-four-and-a-half LIM (LIN-11, Isl-1, MEC-3) domain 5 (FHL5; chr6q16.1),...
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