Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia.

doi:10.1038/s44161-024-00533-w

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Article

Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia.

Nature cardiovascular research - 1 Sept 2024

d'Escamard Valentina, Kadian-Dodov Daniella, Ma Lijiang, Lu Sizhao, King Annette, Xu Yang, Peng Shouneng, V Gangula Bhargravi, Zhou Yu, Thomas Allison, Michelis Katherine C, Bander Emir, Bouchareb Rihab, Georges Adrien, Nomura-Kitabayashi Aya, Wiener Robert J, Costa Kevin D, Chepurko Elena, Chepurko Vadim, Fava Marika, Barwari Temo, Anyanwu Anelechi, Filsoufi Farzan, Florman Sander, Bouatia-Naji Nabila, Schmidt Lukas E, Mayr Manuel, Katz Michael G, Hao Ke, Weiser-Evans Mary C M, Björkegren Johan L M, Olin Jeffrey W, Kovacic Jason C

Abstract excerpt

Fibromuscular dysplasia (FMD) is a poorly understood disease affecting 3-5% of adult females. The pathobiology of FMD involves arterial lesions of stenosis, dissection, tortuosity, dilation and aneurysm, which can lead to hypertension, stroke, myocardial infarction and even death. Currently, there are no animal models for FMD and few insights as to its pathobiology. In this study, by integrating DNA genotype and...

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PMID: 39271816
DOI: 10.1038/s44161-024-00533-w

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