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Parallel recovery of chromatin accessibility and gene expression dynamics from frozen human regulatory T cells

4 Apr 2023

Abstract excerpt

Epigenetic features such as DNA accessibility dictate transcriptional regulation in a cell type- and cell state- specific manner, and mapping this in health vs. disease in clinically relevant material is opening the door to new mechanistic insights and new targets for therapy. Assay for Transposase Accessible Chromatin Sequencing (ATAC-seq) allows chromatin accessibility profiling from low cell input, making it...

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PMID: 37016052
DOI: 10.1038/s41598-023-32256-6

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