Article

Parallel recovery of chromatin accessibility and gene expression dynamics from frozen human Regulatory T cells

2022-08-10

Abstract excerpt

The epigenome and transcriptome constitute a critical element of a tightly regulated, cell-type specific gene expression program, and subtle perturbations in the regulation of this program can result in pathology. Epigenetic features such as DNA accessibility dictate transcriptional regulation in a cell type- and cell state- specific manner, and mapping this in health vs. disease in clinically relevant material is...

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Literature Corpus work: 92d2a6c7-ad05-56f6-bbea-fe065471f88b
DOI: 10.21203/rs.3.rs-1862932/v1

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