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Article

Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.

EMBO reports - 5 Jun 2023

Hsu Po-Chen, Cheng Yu-Hsuan, Liao Chia-Wei, Litan Richard Ron R, Jhou Yu-Ting, Opoc Florica Jean Ganaden, Amine Ahmed A A, Leu Jun-Yi

Abstract excerpt

The discrete steps of transcriptional rewiring have been proposed to occur neutrally to ensure steady gene expression under stabilizing selection. A conflict-free switch of a regulon between regulators may require an immediate compensatory evolution to minimize deleterious effects. Here, we perform an evolutionary repair experiment on the Lachancea kluyveri yeast sef1Δ mutant using a suppressor development...

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Identifiers

PMID: 37009824
DOI: 10.15252/embr.202256019
PMCID: PMC10240213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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