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Article

Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts.

Nucleic acids research - 11 Dec 2024

Hsu Po-Chen, Lu Tzu-Chiao, Hung Po-Hsiang, Leu Jun-Yi

Abstract excerpt

Transcriptional rewiring generates phenotypic novelty, acting as an important mechanism contributing to evolutionary development, speciation, and adaptation in all organisms. The phenotypic outcomes (functions) of transcription factor (TF) activity are determined by the combined effects of all target genes in the TF's regulatory network. Plastic rewiring of target genes accumulates during species divergence and...

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Identifiers

PMID: 39565215
DOI: 10.1093/nar/gkae1147
PMCID: PMC11662654

Genes

TF
NDE1

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