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Article

Intercalation of a new tier of transcription regulation into an ancient circuit.

Nature - 16 Dec 2010

Booth Lauren N, Tuch Brian B, Johnson Alexander D

Abstract excerpt

Changes in gene regulatory networks are a major source of evolutionary novelty. Here we describe a specific type of network rewiring event, one that intercalates a new level of transcriptional control into an ancient circuit. We deduce that, over evolutionary time, the direct ancestral connection...

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Identifiers

PMID: 21164485
DOI: 10.1038/nature09560
PMCID: PMC3254258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21164485-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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