Article
Induced mutations in yeast cell populations adapting to an unforeseen challenge.
PloS one - 1 Jan 2014
Moore Lindsay S, Wei Wu, Stolovicki Elad, Benbenishty Tamar, Wilkening Stefan, Steinmetz Lars M, Braun Erez, David Lior
Abstract excerpt
The modern evolutionary synthesis assumes that mutations occur at random, independently of the environment in which they confer an advantage. However, there are indications that cells facing challenging conditions can adapt rapidly, utilizing processes beyond selection of pre-existing genetic variation. Here, we show that a strong regulatory challenge can induce mutations in many independent yeast cells, in the...
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