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Article

An incoherent feedforward loop facilitates adaptive tuning of gene expression.

eLife - 5 Apr 2018

Hong Jungeui, Brandt Nathan, Abdul-Rahman Farah, Yang Ally, Hughes Tim, Gresham David

Abstract excerpt

We studied adaptive evolution of gene expression using long-term experimental evolution of Saccharomyces cerevisiae in ammonium-limited chemostats. We found repeated selection for non-synonymous variation in the DNA binding domain of the transcriptional activator, GAT1, which functions with the repressor, DAL80 in an incoherent type-1 feedforward loop (I1-FFL) to control expression of the high affinity ammonium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29620523
DOI: 10.7554/eLife.32323
PMCID: PMC5903863

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