Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploration of the role of NKG2D ligands MICA and MICB in JAK2 V617F-positive myeloproliferative neoplasms.

HLA - 1 Aug 2023

Ivanova Milena, Tsvetkova Gergana, Lessichkova Spaska, Gesheva Nevena, Hadjiev Evgueniy, Shivarov Velizar

Abstract excerpt

JAK2 V617F-driven myeloproliferative neoplasms (MPNs) can escape immune surveillance through PD-L1 up-regulation and HLA class I pathway down-regulation. To complement these data we assessed the role of major histocompatibility complex class I-related genes (MICA and MICB) in JAK2 V617F+ MPNs. Using high resolution genotyping we identified two protective alleles, MICA*008:01 and MICA*016. MPN patients had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Janus Kinase 2
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloproliferative Disorders

Share to Neoplasms

Share to NK Cell Lectin-Like Receptor Subfamily K

Source

Identifiers

PMID: 37002719
DOI: 10.1111/tan.15026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploration of the role of NKG2D ligands MICA and MICB in JAK2 V617F-positive myeloproliferative neoplasms.PMID 37002719Read ↗

The relevance of HLA class II genes in JAK2 V617F-positive myeloproliferative neoplasms.Semantic proximity Read ↗

MICA polymorphism: biology and importance in immunity and disease.Semantic proximity Read ↗

Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation.Semantic proximity Read ↗

High-Throughput MICA/B Genotyping of Over Two Million Samples: Workflow and Allele Frequencies.Semantic proximity Read ↗

MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer.Semantic proximity Read ↗

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.Semantic proximity Read ↗

MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.Semantic proximity Read ↗

BCR/ABL Oncogene Directly Controls MHC Class I Chain-Related Molecule A Expression in Chronic Myelogenous LeukemiaSemantic proximity Read ↗

Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.Semantic proximity Read ↗

Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2V617F mutated myeloproliferative disorders.Semantic proximity Read ↗

Diversity and characterization of polymorphic 5' promoter haplotypes of MICA and MICB genes.Semantic proximity Read ↗

Characterization of MICA gene polymorphism of HLA complex in the Slovak population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.