Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.

doi:10.1016/j.humimm.2024.111147

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Soluble MICA concentrations and genetic variability of MICA and its NKG2D receptor as factors affecting Graft-versus-Host Disease development after allogeneic haematopoietic stem cell transplantation.

Human immunology - 1 Nov 2024

Siemaszko Jagoda, Łacina Piotr, Szymczak Donata, Szeremet Agnieszka, Majcherek Maciej, Czyż Anna, Sobczyk-Kruszelnicka Małgorzata, Fidyk Wojciech, Solarska Iwona, Nasiłowska-Adamska Barbara, Skowrońska Patrycja, Bieniaszewska Maria, Tomaszewska Agnieszka, Basak Grzegorz W, Giebel Sebastian, Wróbel Tomasz, Bogunia-Kubik Katarzyna

Abstract excerpt

Despite new treatment strategies, graft-versus-host disease (GvHD) remains a formidable complication after allogeneic hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the impact of polymorphisms and expression of MICA and NKG2D receptor on the development of GvHD in allogeneic HSCT recipients. Soluble MICA (sMICA) concentration was measured in serum collected 30 days after...

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PMID: 39332041
DOI: 10.1016/j.humimm.2024.111147

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