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Article

MICA polymorphism identified by whole genome array associated with NKG2D-mediated cytotoxicity in T-cell large granular lymphocyte leukemia.

Haematologica - 1 Oct 2010

Viny Aaron D, Clemente Michael J, Jasek Monika, Askar Medhat, Ishwaran Hemant, Nowacki Amy, Zhang Aiwen, Maciejewski Jaroslaw P

Abstract excerpt

BACKGROUND: Large granular lymphocyte leukemia is a semi-autonomous clonal proliferation of cytotoxic T cells accompanied by immune cytopenias and various autoimmune conditions. Due to the rarity of this disease and its association with autoimmune diseases, a theoretical germline or somatic mutation might have significant penetrance, thus enabling detection, even from samples of suboptimal size, through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome-Wide Association Study

Share to Histocompatibility Antigens Class I

Share to Leukemia, Large Granular Lymphocytic

Share to NK Cell Lectin-Like Receptor Subfamily K

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Source

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Identifiers

PMID: 20460636
DOI: 10.3324/haematol.2010.021865
PMCID: PMC2948097

Genes

MICA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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