Article
MICA polymorphism: biology and importance in immunity and disease.
Trends in molecular medicine - 1 Mar 2010
Choy Mun-Kit, Phipps Maude E
Abstract excerpt
The human major histocompatibility complex class I chain-related gene A (MICA) is one of the genes in the HLA class I region of chromosome 6. Unlike HLA classical class I gene products, MICA does not present any antigen but acts as a ligand for several immune cells including natural killer (NK) cells bearing NKG2D receptors. MICA is the member of the non-classical class I family that displays the greatest degree...
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