Article
Characterization of MICA gene polymorphism of HLA complex in the Slovak population.
Annals of human biology - 1 Sept 2011
Durmanová V, Tirpakova J, Stuchlikova M, Shawkatova I, Kuba D, Sapak M, Buc M
Abstract excerpt
BACKGROUND: The function of the MHC class I polypeptide-related sequence A (MICA) gene, which belongs to the MHC class I chain-related genes, is to trigger cytolysis of target cells mediated by NKG2D receptor recognition in NK (Natural Killer) cells and CD8 T-lymphocytes. The MICA gene has a high degree of polymorphism, especially observed in exons 2-5. MICA allelic diversity has been reported in association with...
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