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Article

Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation.

Frontiers in immunology - 1 Jan 2021

Machuldova Alena, Holubova Monika, Caputo Valentina S, Cedikova Miroslava, Jindra Pavel, Houdova Lucie, Pitule Pavel

Abstract excerpt

Natural killer cells possess key regulatory function in various malignant diseases, including acute myeloid leukemia. NK cell activity is driven by signals received through ligands binding activating or inhibitory receptors. Their activity towards elimination of transformed or virally infected cells can be mediated through MICA, MICB and ULBP ligands binding the activating receptor NKG2D. Given the efficiency of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33868289
DOI: 10.3389/fimmu.2021.651751
PMCID: PMC8044845

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