Article
BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme.
Histopathology - 1 Jul 2023
Thorne Heather, Devereux Lisa, Li Jason, Alsop Kathryn, Christie Liz, van Geelen Courtney T, Burdett Nikki, Pishas Kathleen I, Woodford Noel, Leditschke Jodie, Izzath Mohamed H M A, Strachan Kate, Young Gregory, Jaravaza Rufaro D, Madadin Mohammed S, Archer Melanie, Glengarry Joanna, Iles Linda, Rathnaweera Ajith, Hampson Clare, Almazrooei Khamis, Burke Michael, Bandara Pradeep, Ranson David, Saeedi Essa, McNally Orla, Mileshkin Linda, Hamilton Anne, Ananda Sumitra, Au-Yeung George, Antill Yoland, Sandhu Shahneen, Savas Peter, Francis Prudence A, Luen Stephen, Loi Sherene, Jennens Ross, Scott Clare, Moodie Kate, Cummings Margaret, Reid Andrew, McCart Reed Amy, Bowtell David, Lakhani Sunil R, Fox Stephen
Abstract excerpt
AIM: To catalogue and compare the pattern of metastatic disease in germline BRCA1/2 pathogenic mutation carriers and non-carriers with breast, ovarian and prostate cancer from a rapid autopsy programme. METHODS AND RESULTS: The number of metastases in the major body systems and the proportion of participants with metastases were documented in 50 participants (19 germline mutation carriers). Analysis was conducted...
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