Article
Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.
Familial cancer - 1 Jul 2017
Saya Sibel, Killick Emma, Thomas Sarah, Taylor Natalie, Bancroft Elizabeth K, Rothwell Jeanette, Benafif Sarah, Dias Alexander, Mikropoulos Christos, Pope Jenny, Chamberlain Anthony, Gunapala Ranga, Izatt Louise, Side Lucy, Walker Lisa, Tomkins Susan, Cook Jackie, Barwell Julian, Wiles Vicki, Limb Lauren, Eccles Diana, Leach Martin O, Shanley Susan, Gilbert Fiona J, Hanson Helen, Gallagher David, Rajashanker Bala, Whitehouse Richard W, Koh Dow-Mu, Sohaib S Aslam, Evans D Gareth, Eeles Rosalind A
Abstract excerpt
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited....
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