Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.

doi:10.1200/JCO.2009.25.1082

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Article

Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 May 2010

Gourley Charlie, Michie Caroline O, Roxburgh Patricia, Yap Timothy A, Harden Sharon, Paul Jim, Ragupathy Kalpana, Todd Radha, Petty Russell, Reed Nick, Hayward Richard L, Mitchell Paul, Rye Tzyvia, Schellens Jan H M, Lubinski Jan, Carmichael James, Kaye Stan B, Mackean Melanie, Ferguson Michelle

Abstract excerpt

PURPOSE: To compare the frequency of visceral relapse of BRCA1/2-deficient ovarian cancer to that of nonhereditary controls. PATIENTS AND METHODS: All patients diagnosed in Scotland with epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC) and a germline BRCA1/2 mutation were identified. Those with previous malignancy were excluded. Each remaining patient who experienced relapse was matched with two...

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PMID: 20406939
DOI: 10.1200/JCO.2009.25.1082

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BRCA1

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