Article
Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2022
Carbone Michele, Pass Harvey I, Ak Guntulu, Alexander H Richard, Baas Paul, Baumann Francine, Blakely Andrew M, Bueno Raphael, Bzura Aleksandra, Cardillo Giuseppe, Churpek Jane E, Dianzani Irma, De Rienzo Assunta, Emi Mitsuru, Emri Salih, Felley-Bosco Emanuela, Fennell Dean A, Flores Raja M, Grosso Federica, Hayward Nicholas K, Hesdorffer Mary, Hoang Chuong D, Johansson Peter A, Kindler Hedy L, Kittaneh Muaiad, Krausz Thomas, Mansfield Aaron, Metintas Muzaffer, Minaai Michael, Mutti Luciano, Nielsen Maartje, O'Byrne Kenneth, Opitz Isabelle, Pastorino Sandra, Pentimalli Francesca, de Perrot Marc, Pritchard Antonia, Ripley Robert Taylor, Robinson Bruce, Rusch Valerie, Taioli Emanuela, Takinishi Yasutaka, Tanji Mika, Tsao Anne S, Tuncer A Murat, Walpole Sebastian, Wolf Andrea, Yang Haining, Yoshikawa Yoshie, Zolondick Alicia, Schrump David S, Hassan Raffit
Abstract excerpt
The most common malignancies that develop in carriers of BAP1 germline mutations include diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and less frequently, breast cancer, several types of skin carcinomas, and other tumor types. Mesotheliomas in these patients are significantly less aggressive, and patients require a multidisciplinary approach that involves genetic counseling,...
Read the complete abstract on PubMed