Article
Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the "Liquid Autopsy".
Scientific reports - 7 Feb 2020
Takai Erina, Maeda Daichi, Li Zhuo, Kudo-Asabe Yukitsugu, Totoki Yasushi, Nakamura Hiromi, Nakamura Akiko, Nakamura Rumi, Kirikawa Misato, Ito Yukinobu, Yoshida Makoto, Inoue Takamitsu, Habuchi Tomonori, Ikoma Shohei, Katoh Hiroto, Kato Mamoru, Shibata Tatsuhiro, Ishikawa Shumpei, Yachida Shinichi, Goto Akiteru
Abstract excerpt
Recent genomic studies on cancer tissues obtained during rapid autopsy have provided insights into the clonal evolution and heterogeneity of cancer. However, post-mortem blood has not been subjected to genetic analyses in relation to cancer. We first confirmed that substantial quantities of cell-free DNA were present in the post-mortem plasma of 12 autopsy cases. Then, we focused on a pilot case of prostate...
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