Article
Sex differences in associations between APOE ε2 and longitudinal cognitive decline.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2023
Wood Madeline E, Xiong Lisa Y, Wong Yuen Yan, Buckley Rachel F, Swardfager Walter, Masellis Mario, Lim Andrew S P, Nichols Emma, Joie Renaud La, Casaletto Kaitlin B, Kumar Raj G, Dams-O'Connor Kristen, Palta Priya, George Kristen M, Satizabal Claudia L, Barnes Lisa L, Schneider Julie A, Binet Alexa Pichette, Villeneuve Sylvia, Pa Judy, Brickman Adam M, Black Sandra E, Rabin Jennifer S
Abstract excerpt
INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants...
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