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Article

APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Sweigart Benjamin, Andersen Stacy L, Gurinovich Anastasia, Cosentino Stephanie, Schupf Nicole, Perls Thomas T, Sebastiani Paola

Abstract excerpt

BACKGROUND: The E4 allele of the APOE gene is known to be associated with cognitive impairment. However, a limited number of studies have examined the association between the E2 allele and longitudinal changes of cognitive function. OBJECTIVE: To determine whether rates of cognitive change differ in carriers of the APOE E2 allele compared to other genotypes. METHODS: We conducted a secondary analysis of data from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34366332
DOI: 10.3233/JAD-201205
PMCID: PMC8896199

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