Article
The presence of resistance-associated mutations in reverse transcriptase gene is associated with cerebrospinal fluid HIV-1 escape: A multicentric retrospective analysis.
Journal of medical virology - 1 Apr 2023
Trunfio Mattia, Pinnetti Carmela, Arsuffi Stefania, Bai Francesca, Celani Luigi, D'Ettorre Gabriella, Vera Jaime H, D'Arminio Monforte Antonella, Focà Emanuele, Ghisetti Valeria, Bonora Stefano, Antinori Andrea, Calcagno Andrea
Abstract excerpt
Higher risk of cerebrospinal fluid escape (CVE) has been associated with the use of specific antiretroviral (ARV) classes, such as protease inhibitors. We assessed whether archived resistance-associated mutations (RAMs) can mediate this relationship by identifying patients treated with incompletely active antiretroviral regimens. A retrospective multicentric study on 282 adult people with HIV on antiretroviral...
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