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Article

A case of HIV encephalopathy with HIV cerebrospinal fluid escape, followed by second-generation integrase inhibitor resistance.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2026

Wang Wen, Yang Jun, Wang Ziqiu, Wen Ying

Abstract excerpt

The management of advanced HIV can be complicated by immune reconstitution inflammatory syndrome (IRIS) and cerebrospinal fluid (CSF) viral escape. We report a novel case of symptomatic CSF escape driven by a rare bictegravir resistance mutation, emerging after a severe unmasking IRIS event. A 61-year-old male patient with advanced HIV (clusters of differentiations 4+ T-cell count 31 cells/μl) initiated...

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AIDS Dementia Complex
Amides
Emtricitabine
Heterocyclic Compounds, 3-Ring
Heterocyclic Compounds, 4 or More Rings

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HIV Integrase Inhibitors

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PMID: 41475656
DOI: 10.1016/j.ijid.2025.108361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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