Article
No difference in HIV-1 integrase inhibitor resistance between CSF and blood compartments.
The Journal of antimicrobial chemotherapy - 12 May 2021
Abdi Basma, Chebbi Mouna, Wirden Marc, Teyssou Elisa, Sayon Sophie, Palich Romain, Seang Sophie, Valantin Marc-Antoine, Simon Anne, Tubiana Roland, Katlama Christine, Calvez Vincent, Marcelin Anne-Geneviève, Soulie Cathia
Abstract excerpt
BACKGROUND: Little is known about HIV-1 integrase inhibitor resistance in the CNS. OBJECTIVES: This study aimed to evaluate integrase inhibitor resistance in CSF, as a marker of the CNS, and compare it with the resistance in plasma. METHODS: HIV integrase was sequenced both in plasma and CSF for 59 HIV-1 patients. The clinical and biological data were collected from clinical routine care. RESULTS: Among the 59...
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