Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma.

doi:10.1093/jac/dku419

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Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Soulie Cathia, Descamps Diane, Grudé Maxime, Schneider Véronique, Trabaud Mary-Anne, Morand-Joubert Laurence, Delaugerre Constance, Montes Brigitte, Barin Francis, Ferre Virginie, Raymond Stéphanie, Jeulin Hélène, Alloui Chakib, Yerly Sabine, Pallier Coralie, Reigadas Sandrine, Signori-Schmuck Anne, Guigon Aurélie, Fafi-Kremer Samira, Haïm-Boukobza Stéphanie, Mirand Audrey, Maillard Anne, Vallet Sophie, Roussel Catherine, Assoumou Lambert, Calvez Vincent, Flandre Philippe, Marcelin Anne-Geneviève

Abstract excerpt

OBJECTIVES: The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. METHODS: Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. RESULTS: On 244...

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PMID: 25344810
DOI: 10.1093/jac/dku419

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