Article
Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Dec 2005
Antinori Andrea, Perno Carlo Federico, Giancola Maria Letizia, Forbici Federica, Ippolito Giuseppe, Hoetelmans Richard M, Piscitelli Stephen C
Abstract excerpt
BACKGROUND: Cerebrospinal fluid (CSF) concentrations of multiple drugs in a large human immunodeficiency virus (HIV)-infected patient population, the virtual phenotype profiles for HIV in the plasma and CSF compartments, and the correlation of these profiles with exposure to antiretroviral therapy need to be further investigated. METHODS: Drug concentrations in CSF and plasma were concomitantly determined for a...
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