Article
Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance.
Virology - 25 Nov 2009
Hightower George K, Letendre Scott L, Cherner Mariana, Gibson Sarah A, Ellis Ronald J, Wolfson Tanya J, Gamst Anthony C, Ignacio Caroline C, Heaton Robert K, Grant Igor, Richman Douglas D, Smith Davey M
Abstract excerpt
BACKGROUND: When antiretroviral therapy does not fully suppress HIV replication, suboptimal levels of antiretrovirals can select for antiretroviral resistant variants of HIV. These variants may exhibit reduced replication capacity and result in lower viral loads in blood. Our study evaluated whether antiretroviral resistance was associated with viral loads in the cerebrospinal fluid (CSF) and better...
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