Article
Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana.
Medicine - 9 Oct 2020
Kelentse Nametso, Moyo Sikhulile, Mogwele Mompati, Lechiile Kwana, Moraka Natasha O, Maruapula Dorcas, Seatla Kaelo K, Esele Lerato, Molebatsi Kesaobaka, Leeme Tshepo B, Lawrence David S, Musonda Rosemary, Kasvosve Ishmael, Harrison Thomas S, Jarvis Joseph N, Gaseitsiwe Simani
Abstract excerpt
To determine effects of cryptococcal meningitis (CM) on human immunodeficiency virus (HIV)-1C cerebrospinal fluid (CSF) viral escape, CSF/plasma viral discordance, and drug resistance mutation (DRM) discordance between CSF and plasma compartments, we compared CSF and plasma viral load (VL) and DRMs in individuals with HIV-associated CM in Botswana.This cross-sectional study utilized 45 paired CSF/plasma samples...
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