Article
Antiretroviral-treated HIV-1 patients can harbour resistant viruses in CSF despite an undetectable viral load in plasma.
The Journal of antimicrobial chemotherapy - 1 Aug 2017
Soulie Cathia, Grudé Maxime, Descamps Diane, Amiel Corinne, Morand-Joubert Laurence, Raymond Stéphanie, Pallier Coralie, Bellecave Pantxika, Reigadas Sandrine, Trabaud Mary-Anne, Delaugerre Constance, Montes Brigitte, Barin Francis, Ferré Virginie, Jeulin Hélène, Alloui Chakib, Yerly Sabine, Signori-Schmuck Anne, Guigon Aurélie, Fafi-Kremer Samira, Haïm-Boukobza Stéphanie, Mirand Audrey, Maillard Anne, Vallet Sophie, Roussel Catherine, Assoumou Lambert, Calvez Vincent, Flandre Philippe, Marcelin Anne-Geneviève
Abstract excerpt
Background: HIV therapy reduces the CSF HIV RNA viral load (VL) and prevents disorders related to HIV encephalitis. However, these brain disorders may persist in some cases. A large population of antiretroviral-treated patients who had a VL > 1.7 log 10 copies/mL in CSF with detectable or undetectable VL in plasma associated with cognitive impairment was studied, in order to characterize discriminatory factors of...
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