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Article

Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain?

Human pathology - 1 Apr 2018

Hühns Maja, Krohn Saskia, Murua Escobar Hugo, Prall Friedrich

Abstract excerpt

Progression of solid cancers, colorectal carcinomas among them, from their primaries to metastatic lesions traditionally is thought to proceed by a stepwise acquisition of and selection for genomic aberrations. To test if patterns of genomic aberrations would be consistent with this model, we studied 10 colorectal carcinoma primary-metastasis pairs, 9 with 1 liver metastasis each and 1 with 2 metastases....

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Source

Identifiers

PMID: 29307628
DOI: 10.1016/j.humpath.2017.12.015

Genes

CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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