Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic insights into the morass of metastatic heterogeneity.

Nature reviews. Cancer - 1 Apr 2018

Hunter Kent W, Amin Ruhul, Deasy Sarah, Ha Ngoc-Han, Wakefield Lalage

Abstract excerpt

Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounded in metastatic disease owing to the complexity of the metastatic process and the multiple biological hurdles that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genetic Heterogeneity
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Cancer Treatments and Mutations

Share to Neoplasm Metastasis

Share to Neoplasms

Share to Neoplasms, Experimental

Source

Open in PubMed Open full text

Identifiers

PMID: 29422598
DOI: 10.1038/nrc.2017.126
PMCID: PMC6290469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic insights into the morass of metastatic heterogeneity.PMID 29422598Read ↗

The Genetic Evolution of Metastasis.Semantic proximity Read ↗

Role of Intratumoral Heterogeneity in Metastatic Progression and Drug ResistanceSemantic proximity Read ↗

Heterogeneity and cancer.Semantic proximity Read ↗

The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcomeSemantic proximity Read ↗

Molecular Profiles of Brain Metastases: A Focus on HeterogeneitySemantic proximity Read ↗

Cancer Genome Evolutionary Trajectories in Metastasis.Semantic proximity Read ↗

Insights into the metastatic cascade through research autopsiesSemantic proximity Read ↗

Minimal functional driver gene heterogeneity among untreated metastases.Semantic proximity Read ↗

Heterogeneity in CancerSemantic proximity Read ↗

Genetic Alterations of Metastatic Colorectal CancerSemantic proximity Read ↗

Somatic variation and cancer: therapies lost in the mix.Semantic proximity Read ↗

Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.