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Single‐cell DNA and surface protein characterization of high hyperdiploid acute lymphoblastic leukemia at diagnosis and during treatment

1 Feb 2025

Abstract excerpt

Abstract High hyperdiploid (HeH) B‐cell acute lymphoblastic leukemia (B‐ALL) is the most prevalent subtype of childhood ALL. This leukemia is characterized by trisomies and tetrasomies of specific chromosomes and additional point mutations. Here, we used single‐cell targeted DNA and antibody sequencing to determine the clonal evolution of HeH B‐ALL during development and chemotherapy treatment. Chromosomal copy...

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PMID: 39944233
DOI: 10.1002/hem3.70085

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