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Article

Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.

Molecular biology of the cell - 1 Aug 2003

Yoshihisa Tohru, Yunoki-Esaki Kaori, Ohshima Chie, Tanaka Nobuyuki, Endo Toshiya

Abstract excerpt

Pre-tRNA splicing has been believed to occur in the nucleus. In yeast, the tRNA splicing endonuclease that cleaves the exon-intron junctions of pre-tRNAs consists of Sen54p, Sen2p, Sen34p, and Sen15p and was thought to be an integral membrane protein of the inner nuclear envelope. Here we show that the majority of Sen2p, Sen54p, and the endonuclease activity are not localized in the nucleus, but on the...

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Identifiers

PMID: 12925762
DOI: 10.1091/mbc.e02-11-0757
PMCID: PMC181566

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Source receipt: pubmed, retrieved 7 Sept 2026.

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