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Article

Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia.

Biology open - 15 Mar 2022

Schmidt Casey A, Min Lucy Y, McVay Michelle H, Giusto Joseph D, Brown John C, Salzler Harmony R, Matera A Gregory

Abstract excerpt

Mature transfer (t)RNAs are generated by multiple RNA processing events, which can include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) complex is responsible for cleaving these intron-containing pre-tRNA transcripts. In humans, TSEN copurifies with CLP1, an RNA kinase. Despite extensive work on CLP1, its in vivo connection to tRNA splicing remains unclear. Interestingly, mutations...

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Identifiers

PMID: 35132432
DOI: 10.1242/bio.058928
PMCID: PMC8935212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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