Article
IDH2 regulates U2AF1 expression and hydroxymethylation in MDS patients.
Biotechnology & genetic engineering reviews - 1 Oct 2024
Cheng Huanchen, Liu Yu, Cheng Mei, Li Wei, Sun Meng, Tang Qinghua, Ma Jun, Li Pu, Gong Tiejun
Abstract excerpt
The expression of some genes regulated by their DNA methylation is involved in pathogenesis and disease progression of myelodysplastic syndrome (MDS), which is characterised by abnormal differentiation and development of myeloid cells. Therefore, it is significant for us to work on investigating what factors regulate U2AF1 expression and hydroxymethylation in MDS patients. However, the members of TET protein...
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