TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes.

doi:10.1182/bloodadvances.2021005418

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Article

TET2 mutations as a part of DNA dioxygenase deficiency in myelodysplastic syndromes.

Blood advances - 11 Jan 2022

Gurnari Carmelo, Pagliuca Simona, Guan Yihong, Adema Vera, Hershberger Courtney E, Ni Ying, Awada Hassan, Kongkiatkamon Sunisa, Zawit Misam, Coutinho Diego F, Zalcberg Ilana R, Ahn Jae-Sook, Kim Hyeoung-Joon, Kim Dennis Dong Hwan, Minden Mark D, Jansen Joop H, Meggendorfer Manja, Haferlach Claudia, Jha Babal K, Haferlach Torsten, Maciejewski Jaroslaw P, Visconte Valeria

Abstract excerpt

Decrease in DNA dioxygenase activity generated by TET2 gene family is crucial in myelodysplastic syndromes (MDS). The general downregulation of 5-hydroxymethylcytosine (5-hmC) argues for a role of DNA demethylation in MDS beyond TET2 mutations, which albeit frequent, do not convey any prognostic significance. We investigated TETs expression to identify factors which can modulate the impact of mutations and thus...

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PMID: 34768283
DOI: 10.1182/bloodadvances.2021005418
PMCID: PMC8753204

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