Article

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty

2024-08-26

Abstract excerpt

Frailty is a clinically relevant phenotype with significant gaps in our understanding of its etiology. We performed a genome-wide association study of frailty in FinnGen (N=500,737) and replicated the signals in the UK Biobank (N=429,463) using polygenic risk scores (PRSs). We prioritized genes through proteomics integration (N∼45,000; UK Biobank) and colocalization of protein quantitative trait loci. Frailty was...

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Literature Corpus work: f488e1a6-a59b-51b0-939b-77c54d17aace
DOI: 10.1101/2024.08.26.24312584

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