Article
Levels of dendritic cell populations and regulatory T cells vary significantly between two commonly used mouse strains.
Scandinavian journal of immunology - 1 Dec 2009
Vogelsang Petra, Hovden Arnt-Ove, Jonsson Roland, Appel Silke
Abstract excerpt
Dendritic cells (DC) are a heterogeneous group of professional antigen-presenting cells (APC) involved in both initiating immune responses and maintaining tolerance. Roughly, DC can be divided into plasmacytoid DC (pDC) and conventional DC (cDC). By controlling regulatory T cells (Treg), DC can influence the outcome of both immunity and autoimmunity. Since the use of mice as in vivo models became a practical tool...
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