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Article

HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer.

British journal of cancer - 22 Aug 2017

Veite-Schmahl Michelle J, Joesten William C, Kennedy Michael A

Abstract excerpt

BACKGROUND: Pancreatic cancer is currently the third leading cause of cancer deaths in the United States and it is predicted to become the second by the year 2030. High-mobility group A1 protein (HMGA1) is an oncogenic transcription factor, localised and active in cell nuclei, that is linked to tumour progression in many human cancers, including pancreatic cancer. Overexpression of HMGA1 renders cancer cells...

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Identifiers

PMID: 28697176
DOI: 10.1038/bjc.2017.216
PMCID: PMC5572173

Genes

HMGA1

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HMGA1 expression levels are elevated in pancreatic intraepithelial neoplasia cells in the Ptf1a-Cre; LSL-KrasG12D transgenic mouse model of pancreatic cancer.PMID 28697176Read ↗

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