Article

HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer

2022-05-30

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely understood. Here we show that the presence of hyaluronan and proteoglycan link protein-1 (HAPLN1) in the extracellular matrix enhances tumor cell plasticity and PDAC metastasis...

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Literature Corpus work: 9426a400-cd20-519b-8781-cc37f6629114
DOI: 10.1101/2022.05.30.493185

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